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pentobarbital decreases levels of toremifene by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers boost level of toremifene metabolism, reducing the continuous-point out focus in serum.fentanyl transmucosal and pentobarbital both raise sedation. Stay clear of or Use Alternate Drug. Restrict use to people